Post-traumatic osteoarthritis (PTOA) is caused by joint injuries leading to progressive degeneration of articular cartilage. PTOA is prevalent in young adults and acute symptoms include swelling, ...

For the first time, researchers have identified and characterized unique cell populations that form the superficial zone of human joint cartilage. The zone has the most critical role in cushioning the ...

Researchers have produced stable joint cartilage from adult stem cells originating from bone marrow. This was made possible by inducing specific molecular processes occurring during embryonic ...

Perlecan is a large heparan sulphate proteoglycan integral to the assembly, maintenance and mechanical responsiveness of cartilage. During embryonic and postnatal cartilage development, perlecan ...

Scientists have pinpointed 145 potential "height genes" in cells that make up the cartilage at the ends of children's bones and affect how tall they grow. These cartilage cells, known as chondrocytes, ...

Cartilage injury is a common cause of joint dysfunction and existing joint prostheses cannot remodel with host joint tissue. However, it is challenging to develop large-scale biomimetic anisotropic ...

In vertebrates, the skeleton of different regions of the body arises from different precursor cells. Researchers at the University of Basel have now discovered that these skeletal cells do not just ...

Researchers at the University of Southampton and the Centre for Human Development, Stem Cells, and Regeneration have developed a new method to generate human cartilage tissue from stem cells. The ...

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In the event of a bone fracture, fatty acids in our blood signal to stem cells that they have to develop into bone-forming cells. If there are no blood vessels nearby, the stem cells end up forming ...